{"id":100162,"date":"2023-08-29T11:50:57","date_gmt":"2023-08-29T11:50:57","guid":{"rendered":"https:\/\/oncogen.ro\/?post_type=project&p=100162"},"modified":"2023-09-05T13:36:10","modified_gmt":"2023-09-05T13:36:10","slug":"proiectul-car-nk","status":"publish","type":"project","link":"https:\/\/oncogen.ro\/ro\/project\/proiectul-car-nk\/","title":{"rendered":"Proiectul CAR-NK"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.22.1″ _module_preset=”default” custom_padding=”0px|0px|0px|0px|true|true” global_colors_info=”{}”][et_pb_row column_structure=”3_5,2_5″ use_custom_gutter=”on” gutter_width=”2″ make_equal=”on” _builder_version=”4.22.1″ _module_preset=”default” width=”100%” max_width=”100%” global_colors_info=”{}”][et_pb_column type=”3_5″ _builder_version=”4.22.1″ _module_preset=”default” background_enable_image=”off” background_size=”contain” global_colors_info=”{}”][et_pb_image src=”https:\/\/oncogen.ro\/wp-content\/uploads\/2023\/08\/car-nk_profu.jpg” title_text=”car-nk_profu” _builder_version=”4.22.1″ _module_preset=”default” border_radii=”on|10px|10px|10px|10px” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb title=” \/\/ Proiect ” content_max_width=”100%” _builder_version=”4.22.1″ _module_preset=”default” header_font=”|600||on|||||” header_font_size=”20px” body_font=”|700||on|||||” body_text_color=”#000000″ body_font_size=”40px” hover_enabled=”0″ header_font_size_tablet=”” header_font_size_phone=”18px” header_font_size_last_edited=”on|phone” body_font_size_tablet=”” body_font_size_phone=”29px” body_font_size_last_edited=”on|phone” custom_css_blurb_title=”color:var(–color-1);padding-bottom:15px;” custom_css_blurb_content=”line-height:45px;color:var(–color-2);” global_colors_info=”{}” custom_css_blurb_content_last_edited=”on|phone” custom_css_blurb_content_phone=”line-height:39px;color:var(–color-2);” custom_css_blurb_content_tablet=”line-height:45px;color:var(–color-2);” sticky_enabled=”0″]<\/p>\n

Project CAR-NK<\/p>\n

[\/et_pb_blurb][et_pb_text _builder_version=”4.22.1″ _module_preset=”default” text_font_size=”17px” text_line_height=”28px” global_colors_info=”{}”]<\/p>\n

https:\/\/carnk.oncogen.ro\/en\/at-a-glance\/<\/a><\/p>\n

[\/et_pb_text][et_pb_blurb title=”Durata proiectului” content_max_width=”100%” module_class=”dct_ptf_dt” _builder_version=”4.22.1″ _module_preset=”default” header_font=”|700||on|||||” header_font_size=”20px” body_font=”|600|||||||” body_font_size=”17px” global_colors_info=”{}”]<\/p>\n

51 de luni<\/p>\n

[\/et_pb_blurb][et_pb_blurb title=”Contract de finan\u021bare” content_max_width=”100%” module_class=”dct_ptf_dt” _builder_version=”4.22.1″ _module_preset=”default” header_font=”|700||on|||||” header_font_size=”20px” body_font=”|600|||||||” body_font_size=”17px” global_colors_info=”{}”]<\/p>\n

\u00a032 din data de 01.09.2016<\/p>\n

[\/et_pb_blurb][et_pb_blurb title=”Parteneri” content_max_width=”100%” module_class=”dct_ptf_dt” _builder_version=”4.22.1″ _module_preset=”default” header_font=”|700||on|||||” header_font_size=”20px” body_font=”|600|||||||” body_font_size=”17px” global_colors_info=”{}”]<\/p>\n

OncoGen-Spitalul Clinic Jude\u021bean de Urgen\u021b\u0103 \u201cPius Br\u00e2nzeu\u201d Timi\u0219oara<\/p>\n

[\/et_pb_blurb][et_pb_blurb title=”Detalii proiect” content_max_width=”100%” module_class=”dct_ptf_dt” _builder_version=”4.22.1″ _module_preset=”default” header_font=”|700||on|||||” header_font_size=”20px” body_font=”|600|||||||” body_font_size=”17px” custom_margin=”||40px||false|false” global_colors_info=”{}”]<\/p>\n

PDF<\/a><\/p>\n

[\/et_pb_blurb][et_pb_blurb title=”ANUN\u021a FINALIZARE PROIECT” content_max_width=”100%” module_class=”dct_ptf_dt” _builder_version=”4.22.1″ _module_preset=”default” header_font=”|700||on|||||” header_font_size=”20px” body_font=”|600|||||||” body_font_size=”17px” custom_margin=”||40px||false|false” global_colors_info=”{}”]<\/p>\n

PDF<\/a><\/p>\n

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” width=”100%” max_width=”100%” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb title=”Sumarul proiectului” content_max_width=”100%” _builder_version=”4.22.1″ _module_preset=”default” header_font=”|700||on|||||” header_font_size=”26px” body_font_size=”17px” body_line_height=”29px” global_colors_info=”{}”]<\/p>\n

CAR-NK este primul proiect rom\u00e2nesc<\/span><\/strong>\u00a0<\/span>ce avanseaz\u0103 ingineria genetic\u0103 a celulelor sistemului imun pentru tratamentul cancerului. Mai exact, celulele Natural Killer (NK), un anumit tip de leucocite responsabile \u00een mod normal de eliminarea celulelor tumorale \u00een faze incipiente, sunt \u00eenarmate cu noi gene ce codeaz\u0103 receptori de antigen chimeric (CARs), receptori ce se leag\u0103 \u00een mod specific de molecule exprimate pe suprafa\u021ba celulelor maligne. Receptorii de antigen chimeric sunt molecule hibride ce con\u021bin module variate ob\u021binute din diferite gene: un modul de direc\u021bionare, reprezentat de obicei de o molecul\u0103 simplificat\u0103 a unui anticorp ce leag\u0103 \u00een mod specific o molecul\u0103 de pe celula \u021bint\u0103, un domeniu transmembranar ce traverseaz\u0103 membrana celular\u0103, \u0219i module intracelulare care activeaz\u0103 trasee celulare citotoxice la momentul leg\u0103rii modulului de direc\u021bionare la \u021binta destinat\u0103.<\/p>\n

Av\u00e2nd \u00een vedere c\u0103 unele tipuri de cancer pot exprima pe suprafa\u021ba celular\u0103 \u021binte specifice, celulele imune precum NK sau celulele T, pot fi modificate s\u0103 recunoasc\u0103 \u0219i s\u0103 atace un anumit tip de celule maligne.<\/p>\n

Spre deosebire de celulele T ob\u021binute prin inginerie, celule care au fost studiate timp de mai multe decenii si au fost aprobate recent pentru utilizare comercial\u0103 ca onco-terapii clinice, celulele NK au fost mai pu\u021bin studiate pentru acest tip de utilizare, reprezent\u00e2nd totu\u0219i o alternativ\u0103 promi\u021b\u0103toare la celulele T pentru tratamentul afec\u021biunilor maligne.<\/p>\n

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” width=”100%” max_width=”100%” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb title=”Obiective” content_max_width=”100%” _builder_version=”4.22.1″ _module_preset=”default” header_font=”|700||on|||||” header_font_size=”26px” body_font_size=”17px” body_line_height=”29px” global_colors_info=”{}”]<\/p>\n

Obiectivul de ansamblu al acestui proiect<\/span><\/strong>\u00a0<\/span>este dezvoltarea, \u00een Rom\u00e2nia, folosind expertiza local\u0103 \u0219i interna\u021bional\u0103, at\u00e2t a activit\u0103\u021bii de cercetare si dezvoltare inovatoare, c\u00e2t \u0219i a posibilit\u0103\u021bilor de tratament \u00een sfera onco-imunologiei.<\/p>\n

Obiectivele opera\u021bionale<\/strong><\/span>\u00a0<\/span>ale proiectului sunt dezvoltarea unor imunoterapii avansate si personalizate pentru variate tipuri de cancer, terapii bazate pe celule CAR-NK, \u0219i crearea primei b\u0103nci de celule umane CAR-NK \u201ddisponibile la raft\u201d (\u201coff the shelf\u201d).<\/p>\n

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” width=”100%” max_width=”100%” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb title=”Rezultate preliminare” content_max_width=”100%” _builder_version=”4.22.1″ _module_preset=”default” header_font=”|700||on|||||” header_font_size=”26px” body_font_size=”17px” body_line_height=”29px” global_colors_info=”{}”]<\/p>\n