Experimental Medicine Department

Short description:

​The compartment is the in vivo test area where isolated organ bath studies, animal models for different types of tumors, studies on isolated muscle fiber, spirometry, Langendorff, in vivo imaging studies are performed. Furthermore, biomatrics can be obtained by decellularization procedures for tissue regeneration experiments. The compartment is equipped with a laboratory biobase of small animals, operating room, complex intraoperative monitoring systems (pulse, blood pressure, ventilation, electrocardiogram, temperature, etc.), vital support systems during surgical interventions (assisted ventilation, extracorporeal circulation, etc.), equipment and laboratories for experimental medicine.

​Main activities / techniques:

• ​tumor models in vivo, imaging studies in vivo
• obtaining biomatrics for tissue regeneration
• in vivo toxicology experiments
• experiments on the isolated heart – Langendorff model; respirometry studies
• investigations in the isolated organ bath

​Staff:

• ​Coordinator: Ada Cean, Biotech Eng., PhD
• Alexandra Ivan, Biotech Eng., PhD
• Mirabela Cristea, Biol. Principal, PhD
• Camelia Oprean, Pharm., PhD

Equipment:

• ​Tissue homogenizer
• Apparatus for studies on insulated fiber
• Vital functions complex monitor
• Small animal ventilation device with accessories
• Peristaltic pump and accessories
• In vivo imaging system Hamamatsu Aequoria
• Oxygen Electrode Clark HANSATECH Oxygraph
• OROBOROS Oxygraph 2k
• Langendorff device
• Apollo 4000 4-channel complex analyzer with associated electrodes
• Fiber optic endocavity pressure pickup device
• Plate for acquisition of biological signals with acquisition software
• Vital functions complex monitor: electrocardiogram, respiratory rate, temperature, invasive pressure, electroencephalogram, bispectral index and consumables