Clinical Toxicology Laboratory

Short presentation:
The lab serves as a facility for the diagnosis of acute and chronic intoxications with unknown chemicals. Using various biological specimens from patients (whole blood, serum, urine, hair), our laboratories can detect various toxic organic substances (including drugs of abuse, narcotics, pesticides) as well as toxic metals and metalloids. The state of the art HPLC and GC systems are used for organic molecules identification, while an atomic absorption spectrophotometer (equipped with both furnace and graphite oven) is employed for metal analyses.

Main activities/techniques:

  • biological sample acquisition – a variety of specimen types for toxicological analysis: whole blood, serum, hair, urine, saliva, tissue samples (fresh or paraffin embedded)
  • sample processing by chemical procedures for purification and concentration of the unknown toxicants of interest
  • sample analysis: based on the clinical diagnosis, organic molecules or metals, or a full spectrum analysis can be performed
  • data acquisition and molecular identification of the target unknown compounds, for an accurate toxicological diagnosis

Personnel:
Coordinator: Calin Tatu, MD, PhD
Alexandra Gruia, Principal Chem. Res., PhD
Technicians

Equipment:

  • HPLC-MS quadrupole system (Brucker)
  • HPLC system with variable lengthwave detector (Agilent)
  • GC-MS systems (Brucker, Agilent)
  • GC-FID systems (Brucker, Agilent)
  • Atomic Absorbtion Spectrophotometry (Brucker)

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